Tylosin
Tylosin
- CAS:
- 1401-69-0
- MF:
- C46H77NO17
- MW:
- 916.1
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Properties
- Melting point:
- 135-137°C
- alpha
- D25 -46° (c = 2 in methanol)
- Boiling point:
- 796.05°C (rough estimate)
- Density
- 1.1424 (rough estimate)
- refractive index
- 1.5280 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml
- form
- A crystalline solid
- pka
- pKa 7.73(H2O t = 25 I = 0.167) (Uncertain)
- color
- White to light yellow
- Water Solubility
- H2O: soluble 50 mg/mL
- Stability:
- Solutions are stable at pH 4-9 (most stable at pH 7);
Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis;
In neutral and alkaline pH – tylosin aldol (TAD) is formed together with polar degradation products of unknown identity;
When tylosin solution is exposed to daylight, a photodegradation product - isotylosin A (isoTA) is formed.
- InChIKey
- WBPYTXDJUQJLPQ-VMXQISHHSA-N
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H317-H334
- Precautionary statements
- P261-P272-P280-P284-P302+P352-P333+P313
- Hazard Codes
- Xn,N
- Risk Statements
- 42/43-50
- Safety Statements
- 36-61-45-36/37-22
- HS Code
- 2941906000
- Toxicity
- Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.
Use
Tylosin is a 16-membered macrocyclic lactone isolated from Streptomyces fradiae in 1961. Tylosin has broad spectrum antibacterial activity and was developed as a veterinary pharmaceutical for treatment of bacterial infections in a range of domestic animals . Tylosin acts by binding to the 50S ribosomal subunit resulting in the inhibition of protein synthesis in bacteria.
2 India supplier list of "Tylosin"
- Product Name:Tylosin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Tylosin
- Products Intro:Brand:sigma aldrich | Product Number:PHR2652 | Purity:certifiedreferencematerial,pharmaceuticalsecondarystandard
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Tylosin(1703805)
- Products Intro:Brand:pharmaffiliates | Product Number:PAUSP1703805
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Tylosin
- Company Type: Reagent
- Country/Region: Mumbai,INDIA