A77 1726
A77 1726
- CAS:
- 163451-81-8
- MF:
- C12H9F3N2O2
- MW:
- 270.21
Suppliers by country/region
Company Type
Properties
- Melting point:
- 229-232°C
- Boiling point:
- 410.8±45.0 °C(Predicted)
- Density
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 5.20±0.50(Predicted)
- form
- powder
- color
- white to beige
- λmax
- 203nm(MeOH)(lit.)
- Merck
- 14,9165
- Stability:
- Hygroscopic
- InChIKey
- UTNUDOFZCWSZMS-YFHOEESVSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H225-H302+H312+H332-H319
- Precautionary statements
- P210-P280-P301+P312-P303+P361+P353-P304+P340+P312-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22
- WGK Germany
- 3
- HS Code
- 2926.90.4801
Use
A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]
5 India supplier list of "A77 1726"
![](/images/pro-3.jpg)
- Product Name:Leflunomide EP Impurity B Leflunomide USP RC B ; (Z)-2-cyano-3-hydroxy-N-(4- (trifluoromethyl) phenyl)but-2-enamide
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
![](/images/pro-3.jpg)
- Product Name:Teriflunomide
- Products Intro:Brand:sigma aldrich | Product Number:SML0936 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
![](/images/pro-3.jpg)
- Product Name:LeflunomideEPImpurityB
- Products Intro:Brand:synzeal | Product Number:736056774
- Company Type: Trader
- Country/Region: Gujarat,INDIA
![](/images/pro-3.jpg)
- Product Name:A77 1726
- Company Type: Reagent
- Country/Region: Haryana,INDIA
![](/images/pro-3.jpg)
- Product Name:A77 1726
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
![](/images/pro-3.jpg)
- Product Name:Teriflunomide
- Products Intro:Brand:pharmaffiliates | Product Number:PA1208020
- Company Type: Trader
- Country/Region: Haryana,INDIA