Acebutolol
Acebutolol
- CAS:
- 37517-30-9
- MF:
- C18H28N2O4
- MW:
- 336.43
Suppliers by country/region
Company Type
Properties
- Melting point:
- 119-123°C
- Boiling point:
- 472.9°C (rough estimate)
- Density
- 1.1748 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 5 mg/mL,PBS (pH 7.2): 0.3 mg/mL
- form
- A solid
- pka
- pKa 9.40 (Uncertain)
- color
- Crystals
- Water Solubility
- 259 mg/L
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H362
- Precautionary statements
- P201-P260-P263-P264-P270-P308+P313
- Toxicity
- TDLo orl-wmn: 152 mg/kg:CVS,BPR JTCTDW 20,69,83
Use
Acebutolol is one of the very few β-blockers whosemetabolite plays a significant role in its pharmacological actions.This drug is absorbed well from the gastrointestinaltract, but it undergoes extensive first-pass metabolic conversionto diacetolol by hydrolytic conversion of the amidegroup to the amine, followed by acetylation of the amine. After oral administration, plasma levels of diacetololare higher than those of acebutolol. Diacetolol is also aselective β1-blocker with partial agonistic activity; it has littlemembrane-stabilizing activity. It has a longer half-life (8–12hours) than the parent drug and is excreted by the kidneys.
8 India supplier list of "Acebutolol"
- Product Name:Acebutolol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Acebutolol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Haryana,INDIA
- Product Name:Acebutolol 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.147596
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Acebutolol
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Acebutolol
- Products Intro:Brand:ajchemicals | Product Number:JDH-68839 | Purity:95%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Acebutolol
- Products Intro:Brand:pharmaffiliates | Product Number:PA013300000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Acebutolol
- Products Intro:Brand:synzeal | Product Number:162087881
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Acebutolol
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Acebutolol
- Company Type: Reagent
- Country/Region: Vadodara,INDIA
- Product Name:Acebutolol
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA