Acebutolol
- CAS No.
- 37517-30-9
- Chemical Name:
- Acebutolol
- Synonyms
- Prent;Sectral;ACEBUTOLOL;Acebutololum;Acetobutolol;dl-Acebutolol;Acebutolo HCl;Acebutolol USP/EP/BP;AcebutololDiscontinued. See: A123800;3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide
- CBNumber:
- CB5393651
- Molecular Formula:
- C18H28N2O4
- Molecular Weight:
- 336.43
- MOL File:
- 37517-30-9.mol
- Modify Date:
- 2023/6/8 9:03:05
| Melting point | 119-123°C |
|---|---|
| Boiling point | 472.9°C (rough estimate) |
| Density | 1.1748 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 5 mg/mL,PBS (pH 7.2): 0.3 mg/mL |
| form | A solid |
| pka | pKa 9.40 (Uncertain) |
| color | Crystals |
| Water Solubility | 259 mg/L |
| CAS DataBase Reference | 37517-30-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Acebutolol(37517-30-9) |
| EPA Substance Registry System | Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- (37517-30-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H362 | |||||||||
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 | |||||||||
| Toxicity | TDLo orl-wmn: 152 mg/kg:CVS,BPR JTCTDW 20,69,83 | |||||||||
| NFPA 704 |
|
Acebutolol Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Cardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)
Definition
ChEBI: An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.
General Description
Acebutolol is one of the very few β-blockers whosemetabolite plays a significant role in its pharmacological actions.This drug is absorbed well from the gastrointestinaltract, but it undergoes extensive first-pass metabolic conversionto diacetolol by hydrolytic conversion of the amidegroup to the amine, followed by acetylation of the amine. After oral administration, plasma levels of diacetololare higher than those of acebutolol. Diacetolol is also aselective β1-blocker with partial agonistic activity; it has littlemembrane-stabilizing activity. It has a longer half-life (8–12hours) than the parent drug and is excreted by the kidneys.
Clinical Use
Acebutolol (Sectral) is a cardioselective 1-adrenoceptor blocking agent that also has some minor membrane stabilizing effects on the action potential. Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventricular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.
Side effects
Adverse effects include bradycardia, gastrointestinal upset, dizziness, and headache.
Safety Profile
Moderately toxic by intravenousroute. Human systemic effects by ingestion: developmentalabnormalities of the cardiovascular and respiratory systems;effects on newborn in biochemical and metabolicabnormalities and reduced growth statistics. A humanter
Metabolism
About half of an orally administered dose of acebutolol (Sectral) is absorbed. Approximately 25% of the drug is bound to plasma proteins, and its plasma halflife is about 4 hours.Metabolism of acebutolol produces a metabolite with -blocking activity whose half-life is 10 hours.
Precautions
Acebutolol should not be administered in cardiogenic shock, uncontrolled heart failure, or severe bradycardia or to patients with known hypersensitivity to the drug.
Acebutolol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| GLP Pharma Standards | 08069033853Ext 142 | Hyderabad, India | 54 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Excel International | 08048957044 | Mumbai, India | 36 | 58 | Inquiry |
| Luna Chemical Industries Private Limited | 08048372754Ext 585 | Vadodara, India | 22 | 58 | Inquiry |
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