Amifostine
Amifostine
- CAS:
- 20537-88-6
- MF:
- C5H15N2O3PS
- MW:
- 214.22
Suppliers by country/region
Company Type
Properties
- Melting point:
- 160-1610C
- Boiling point:
- 441.7±51.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Water.
- form
- powder
- pka
- 1.28±0.10(Predicted)
- color
- White
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- TE6491000
- Toxicity
- cyt-mus-ipr 300 mg/kg CUSCAM 54,1080,85
Use
Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.
6 India supplier list of "Amifostine"
- Product Name:Amifostine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amifostine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Amifostine
- Products Intro:Brand:pharmaffiliates | Product Number:PA5435000
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Amifostine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amifostine
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Amifostine
- Products Intro:Purity: 99% | Package: 1kg;2USD
- Company Type: Reagent
- Country/Region: CHINA
$2.00/ 1kg