Amrubicin
AMRUBICIN
- CAS:
- 110267-81-7
- MF:
- C25H25NO9
- MW:
- 483.47
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Properties
- Melting point:
- 172-1740C
- alpha
- D20 +119° (c = 0.02 in CHCl3)
- Boiling point:
- 717.8±60.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- >16.45mg/mL in DMSO
- form
- Powder
- pka
- 7.83±0.60(Predicted)
- color
- Pink to red
Safety Information
Use
Amrubicin is an active agent for the treatment of small-cell lung cancer (SCLC). It is a type of anthracycline analog. Anthracycline derivatives such as doxorubicin (DXR), daunorubicin (DNR) and epirubicin have been widely used for a variety of carcinomas in the clinical context. Amrubicin is structurally distinguishable from other anthracyclines by the amino group at the 9-position and its unique sugar moiety. In April 2002, Amrubicin was approved in Japan for the treatment of non-small cell lung cancer and small cell lung cancer.
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