Apoptolidin
Apoptolidin
- CAS:
- 194874-06-1
- MF:
- C58H96O21
- MW:
- 1129.38
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Properties
- Melting point:
- 128-130°
- alpha
- 21D -5.2° (c = 1.0 in methanol)
- Boiling point:
- 1108.9±65.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- Flash point:
- 87℃
- storage temp.
- -20°C
- solubility
- Soluble in DMSO, DMF, ethanol, or methanol.
- pka
- 11.71±0.70(Predicted)
- form
- DMSO solution
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319
- Precautionary statements
- P264-P270-P280-P301+P312-P330-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 2
Use
Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
0 India supplier list of "Apoptolidin"
- Product Name:ApoptolidinAReadyMadeSolution
- Products Intro:Brand:sigma aldrich | Product Number:SML0907 | Purity:1?mg/mLinDMSO
- Company Type: Trader
- Country/Region: INDIA
-
0.1MG$436.00
- Product Name:APOPTOLIDIN
- Products Intro:Brand:Acccorporation | OriginalID:API0019258 | Purity:95.00%
- Company Type: Trader
- Country/Region: UNITED STATES