Artemisinin manufacturers and suppliers in india

Artemisinin

Properties

Melting point:: 156-157 °C (lit.)

alpha: 76 º (c=0.5,MeOH)

Boiling point:: 344.94°C (rough estimate)

Density: 1.0984 (rough estimate)

refractive index: 75 ° (C=0.5, MeOH)

storage temp.: -20°C

solubility: Soluble to 100mM in DMSO and to 75mM in ethanol

form: White to off-white crystalline solid.

color: Needles

optical activity: [α]20/D +76°, c = 0.5 in methanol

Merck: 14,817

Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.

InChI: InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

InChIKey: BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES: O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1

LogP: 2.900

Safety Information

Symbol(GHS): GHS02,GHS09

Signal word: Warning

Hazard statements: H242-H400-H410

Precautionary statements: P210-P220-P234-P280-P280-P273-P391-P420-P410

Safety Statements: 22-24/25

WGK Germany: 2

RTECS: KD4170000

HS Code: 29322985

Toxicity: LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)

Use

Artemisia annua is used as antimalarial drugs. Clinical application has shown that artemisinin and its derivatives have special effects on treating the malaria and falciparum malaria, especially artemisinin which has stronger killing effect on Plasmodium falciparum intracellular phorozoon than other artemisinin drugs, characterized by high efficiency, rapid efficacy, low toxicity and no cross-resistance with chloroquine, etc. It can be not only used for treatment, but also for emergency treatment. It is applicable to a variety of malaria such as falciparum malaria, vivax malaria, anti-chloroquine malaria and cerebral malaria, including dangerous type.