Astemizole manufacturers and suppliers in india

Astemizole

Properties

Melting point:: 172.9°C

Boiling point:: 627.3±65.0 °C(Predicted)

Density: 1.1587 (estimate)

storage temp.: 2-8°C

solubility: DMSO: >20mg/mL

pka: pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)

form: powder

color: Crystals

Water Solubility: It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36

RIDADR: UN 2811 6.1 / PGII

WGK Germany: 3

RTECS: DD8968000

HS Code: 2933992600

Toxicity: LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81

Use

Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.