Atosiban
Atosiban
- CAS:
- 90779-69-4
- MF:
- C43H67N11O12S2
- MW:
- 994.19
Suppliers by country/region
Company Type
Properties
- Melting point:
- >165oC (dec.)
- Boiling point:
- 1469.0±65.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: ≤100 mg/mL
- form
- solid
- pka
- 12.81±0.70(Predicted)
- color
- White to Off-White
- Water Solubility
- Soluble to 50 mg/ml in water
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P271-P261-P280
- WGK Germany
- 3
- RTECS
- RS7590000
- HS Code
- 2934999090
Use
Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.
4 India supplier list of "Atosiban"
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- Product Name:Atosiban
- Products Intro:Brand:sigma aldrich | Product Number:A3480 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
![](/images/pro-3.jpg)
- Product Name:AtosibanImpurity1
- Products Intro:Brand:synzeal | Product Number:236343701
- Company Type: Trader
- Country/Region: Gujarat,INDIA
![](/images/pro-3.jpg)
- Product Name:Atosiban
- Company Type: Reagent
- Country/Region: Haryana,INDIA
![](/images/pro-3.jpg)
- Product Name:Atosiban
- Products Intro:Brand:pharmaffiliates | Product Number:PA2837000
- Company Type: Trader
- Country/Region: Haryana,INDIA