Baicalein manufacturers and suppliers in india

Baicalein

Properties

Melting point:: 256-271 °C (lit.)

Boiling point:: 373.35°C (rough estimate)

Density: 1.3280 (rough estimate)

refractive index: 1.5000 (estimate)

storage temp.: Keep in dark place,Sealed in dry,2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

form: Yellow solid

pka: 6.31±0.40(Predicted)

color: Yellow or yellow-green

Merck: 14,942

BRN: 272683

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

InChIKey: FXNFHKRTJBSTCS-UHFFFAOYSA-N

LogP: 3.310 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes: Xi,Xn

Risk Statements: 36/37/38-20/21/22

Safety Statements: 26-36

WGK Germany: 3

RTECS: DJ3100898

Hazard Note: Irritant

HS Code: 29329990

Use

Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml.