Bexarotene
Bexarotene
- CAS:
- 153559-49-0
- MF:
- C24H28O2
- MW:
- 348.48
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Company Type
Properties
- Melting point:
- 230-231°C
- Boiling point:
- 489.7±44.0 °C(Predicted)
- Density
- 1.042
- RTECS
- DH6834830
- storage temp.
- -20°C
- solubility
- Soluble in DMSO and ethanol
- pka
- 4.08±0.10(Predicted)
- form
- White powder
- color
- white to beige
- λmax
- 264nm(MeOH)(lit.)
- Merck
- 14,1194
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- NAVMQTYZDKMPEU-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- WGK Germany
- 3
- HS Code
- 29163990
Use
Bexarotene was launched in the US for the treatment of manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. The four step synthesis of bexarotene involves a double Friedel-Craft alkylation of toluene with 2,5-dichloro-2,5-dimethylhexane followed by acylation with monomethylterephthalic acid chloride, then Wittig methylidenation. Bexarotene is the first retinoid X receptor (RXR) agonist to be selective versus retinoid A receptors (RAR). Its activation of the three RXRα, β, γ isoforms induces cell differentiation and apoptosis and inhibits cell proliferation in several models of cancer. In phase ll/lll clinical trials, 48% of patients with refractory or persistent early-stage cutaneous T-cell lymphoma achieved a complete or partial response when treated with 300 mg/m2/day of bexarotene. It was shown in phase I trials that this second-generation retinoid was substantially less toxic than the broad-spectrum or RARselective retinoids.
22 India supplier list of "Bexarotene"
- Product Name:Bexarotene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Bexarotene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Bexarotene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Bexarotene
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Bexarotene-CAS153559-49-0-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:200499 | Purity:AretinoidXreceptor(RXR)agonistthatcanpermeatetheblood-brainbarrierandrapidlyredu
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Bexarotene >98% (HPLC)
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.071946
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Bexarotene
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Bexarotene
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Bexarotene
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Bexarotene
- Products Intro:Brand:synzeal | Product Number:309867494
- Company Type: Trader
- Country/Region: INDIA