Bufalin manufacturers and suppliers in india

Bufalin

Properties

Melting point:: 242-243°

alpha: D -20°

Boiling point:: 556.6±50.0 °C(Predicted)

Density: 1.226±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM)
Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM)

pka: 15.01±0.70(Predicted)

form: White to off-white solid

color: White to off-white

InChIKey: QEEBRPGZBVVINN-ONGIWDLKSA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P301+P310+P330

Hazard Codes: T+

Risk Statements: 28

Safety Statements: 28-36/37-45

RIDADR: UN 3462 6.1/PG 2

WGK Germany: 3

RTECS: EI2962500

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29322090

Use

Bufalin is one of the main components of dried secretions of toad which is Bufo , Bufalin has a strong surface anesthetic effect, and it has a long-lasting effect in rabbit cornea and human tongue tests which is stronger than cocaine, about 90 times of cocaine. intravenous fluid Toad (0.05mg/kg) on Anesthetized rabbits , anesthetized rabbits can be caused breathing excitement, cat can also be caused breathe excitement . Its effect is stronger than nikethamide , pentylenetetrazol, lobeline, etc. and it can antagonize morphine respiratory depression. Respiratory stimulant order: Bufalin>Resibufogenin= Cinobufagin =cinobufotaline> Japanese toad toxins. Bufalin low concentrations (10-4) promote release of presynaptic acetylcholine on rat diaphragm , while high concentrations promote first then inhibit, and partly antagonize the neuromuscular blocking effects of Mg2 +,but no inhibition on choline esterase. The above information is edited by the Chemicalbook of Tian Ye.