CALCIFEDIOL manufacturers and suppliers in india

CALCIFEDIOL

Properties

Melting point:: 74-76oC

Boiling point:: 529.2±33.0 °C(Predicted)

Density: 1.01±0.1 g/cm3(Predicted)

Flash point:: 14 °C

storage temp.: -20°C

solubility: DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml

form: White to off-white crystalline solid.

pka: 14.74±0.20(Predicted)

color: White to off-white

Stability:: Light Sensitive, Temperature Sensitive

InChIKey: JWUBBDSIWDLEOM-DTOXIADCSA-N

Safety Information

Symbol(GHS): GHS02,GHS07

Signal word: Danger

Hazard statements: H225-H319

Precautionary statements: P210-P305+P351+P338

Hazard Codes: T+,F

Risk Statements: 28-48/25-26-24/25-11

Safety Statements: 28-36/37-45-16-7

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

F: 8-10-19

HazardClass: 6.1

PackingGroup: Ⅱ

HS Code: 29362900

Use

Calcifediol (synonym 25-Hydroxyvitamin D3) is a vitamin D analog and the major metabolite of vitamin D3 (Cholecalciferol) in the liver. Its main function is the regulation of calcium and phosphorus, which is necessary for strong bones. It is used to treat patients with serious kidney diseases to decrease the parathyroid hormone (PTH) level. It is used to treat rickets and osteomalacia, both in azotemic and non-azotemic patient. Calcifediol is sold under RAYALDEE to treat secondary hyperparathyroidism associated with vitamin D insufficiency in stage 3-4 chronic kidney disease.