Cefixime manufacturers and suppliers in india

Cefixime

Properties

Melting point:: 218-225°C

Density: 1.85±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate.

pka: pKa 2.10 (Uncertain)

form: Solid

color: Off-White to Pale Yellow

Water Solubility: 55.11 mg/L

BCS Class: 4

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 42/43

Safety Statements: 22-36/37-45

WGK Germany: 3

F: 10-23

HS Code: 38210000

Toxicity: LD50 oral in rat: > 10gm/kg

Use

Cefixime is a broad-spectrum cephalosporin that is resistantto many β-lactamases. it is particularly effective againstgram-negative bacilli, including e. coli, klebsiella spp., p.mirabilis, indole-positive proteus, providencia, and somecitrobacter spp. most pseudomonas, enterobacter, andbacteroides spp. are resistant. it also has useful activityagainst streptococci, gonococci, h. influenzae, and m. catarrhalis.it is much less active against s. aureus. cefixime isused for the treatment of various respiratory tract infections(e.g., acute bronchitis, pharyngitis, and tonsillitis) and otitismedia. it is also used to treat uncomplicated urinary tract infectionsand gonorrhea caused by β-lactamase–producingbacterial strains.