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COCAINE

COCAINE

CAS:
50-36-2
MF:
C17H21NO4
MW:
303.35

Properties

Melting point:
98°
alpha 
D18 -35° (50% alcohol); D20 -16° (c = 4 in chloroform)
Boiling point:
bp0.1 187-188°
Density 
1.1014 (rough estimate)
refractive index 
1.5022 (estimate)
Flash point:
2℃
storage temp. 
2-8°C
solubility 
DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form 
A neat solid
pka
pKa (15°) 8.61; pKb (15°) 5.59
Water Solubility 
1.664g/L(25 ºC)
Dielectric constant
3.1(20.0℃)

Safety Information

Symbol(GHS) 
GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word 
Danger
Hazard statements 
H300+H330-H336-H361d
Precautionary statements 
P202-P260-P264-P270-P271-P304+P340+P310
Hazard Codes 
T,Xn,F
Risk Statements 
23/24/25-43-36-20/21/22-11
Safety Statements 
26-36/37-45-36/37/39-22-16
RIDADR 
UN 1648 3/PG 2
WGK Germany 
3
RTECS 
YM2800000
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
LD50 i.v. in rats: 17.5 mg/kg (Rose)

Use

Cocaine and its derivatives are still popular local anesthetics in operations of the ear, nose and throat and it is also used in a preparation given to alleviate the pain (physical and mental) of terminal diseases.

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COCAINECOCAETHYLENE
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