Deferiprone
Deferiprone
- CAS:
- 30652-11-0
- MF:
- C7H9NO2
- MW:
- 139.15
Suppliers by country/region
Company Type
Properties
- Melting point:
- 272-275 °C (lit.)
- Boiling point:
- 255.1°C (rough estimate)
- Density
- 1.1997 (rough estimate)
- refractive index
- 1.4800 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in Water (up to 5 mg/ml with warming).
- form
- Crystalline Powder or Needles
- pka
- pKa1 3.3, pKa2 9.7(at 25℃)
- color
- White to off-white
- Water Solubility
- Soluble in hot water
- Merck
- 14,2859
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
- InChI
- InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
- InChIKey
- TZXKOCQBRNJULO-UHFFFAOYSA-N
- SMILES
- C1(C)N(C)C=CC(=O)C=1O
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P301+P312+P330
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- UU7785940
- HS Code
- 29333990
- Toxicity
- LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)
Use
Deferiprone, the first oral iron chelator, was marketed in India for the management of thalassaemia. Patients with thalassaemia, a blood related genetic disorder, require life time transfusion which causes excessive deposition of iron in liver and spleen, subsequent damage to organs and eventually death unless iron is removed by a chelator. Deferiprone is a potent iron chelator that mobilizes excessive iron from iron storage proteins ferritin and hemosiderin, from iron saturated transferrin and lactoferrin, but not from hemoglobin. The deferiprone-iron complex is excreted in urine and bile. Deferiprone was reportedly well accepted by patients and no hematological toxicity was observed. Deferiprone has also been demonstrated as an effective and safe chelator in the mobilization of aluminum.
38 India supplier list of "Deferiprone"
- Product Name:Deferiprone
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: NaviMumbai,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Kerela,INDIA
- Product Name:Deferiprone
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
- Products Intro:Brand:sigma aldrich | Product Number:379409 | Purity:98%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Deferiprone 99% (HPLC), powder
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.072078
- Company Type: Trader
- Country/Region: New Delhi,INDIA