Di-tert-butyl dicarbonate
Di-tert-butyl dicarbonate
- CAS:
- 24424-99-5
- MF:
- C10H18O5
- MW:
- 218.25
Suppliers by country/region
Company Type
Properties
- Melting point:
- 23 °C (lit.)
- Boiling point:
- 56-57 °C/0.5 mmHg (lit.)
- Density
- 0.95 g/mL at 25 °C (lit.)
- vapor pressure
- 3.85Pa at 25℃
- refractive index
- n
20/D 1.409(lit.)
- Flash point:
- 99 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Low Melting Crystalline Solid
- color
- White
- Specific Gravity
- 0.950
- Water Solubility
- Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
- Sensitive
- Moisture Sensitive
- BRN
- 1911173
- Stability:
- Acid Sensitive
- InChIKey
- DYHSDKLCOJIUFX-UHFFFAOYSA-N
- LogP
- 1.87 at 25℃
Safety Information
- Symbol(GHS)
GHS02,GHS05,GHS06
- Signal word
- Danger
- Hazard statements
- H226-H315-H317-H318-H330-H335
- Precautionary statements
- P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
- Hazard Codes
- T+,T,F,Xi,F+
- Risk Statements
- 11-19-26-36/37/38-43-10-40
- Safety Statements
- 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
- RIDADR
- UN 2929 6.1/PG 1
- WGK Germany
- 3
- RTECS
- HT0230000
- Autoignition Temperature
- 460 °C
- Hazard Note
- Flammable/Irritant/Very Toxic
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- I
- HS Code
- 29209010
- Toxicity
- LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Use
Di-tert-butyl dicarbonate (Boc2O) and di-tert-butyl tricarbonate ((BocO)2CO) have been used as amine carbonylating reagents to obtain linear or branched aliphatic isocyanates. most of the known methods for transforming amines into isocyanates are not mild enough and furnish undefined products as a result of uncontrolled side reactions. However, 4-dimethylaminopyridine (DMAP)-catalyzed reaction with activated carbonates as C1 building blocks constitutes a convenient laboratory method for the phosgene-free isocyanation of amines. A procedure has been described whereby alkyl- and arylamines are converted into isocyanates in high yields by reaction with activated carbonates (for example, di-tert-butyl dicarbonate, Boc2O) in the presence of a catalytic amount of a nucleophilic nitrogen base at room temperature. Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. The reaction of substituted anilines with Boc2O in the presence of a stoichiometric amount of 4-dimethylaminopyridine (DMAP) in an inert solvent (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) at room temperature leads to aryl isocyanates in almost quantitative yields within 10 min.
76 India supplier list of "Di-tert-butyl dicarbonate"
- Product Name:Boc-anhydride, 98%
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:BOC ANHYDRIDE
- Products Intro:Purity: Min 98% | Package: 1Kg, 5Kg, 25Kg 100Kg, MT
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Di Tert Butyl Bicarbonate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Boc anhydride
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Di-tert-butyl dicarbonate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Di-tert-butyl dicarbonate (Bocanhydride),
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:BOC-Anhydride
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Di-tert-butyl di carbonate (BOC anhydride)
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA