Dicloxacillin sodium manufacturers and suppliers in india

Dicloxacillin sodium

Properties

Melting point:: 222-225°C

alpha: D20 +127.2° (water)

storage temp.: 2-8°C

solubility: H2O: soluble50mg/mL

form: powder

color: white to off-white

Water Solubility: Soluble in water

BRN: 4778711

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H315-H319-H334-H335

Precautionary statements: P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 36/37/38-42/43

Safety Statements: 22-26-36/37-45

WGK Germany: 2

RTECS: XH8925000

HS Code: 29411099

Toxicity: LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber)

Use

The substitution of chlorine atoms on both carbons orthoto the position of attachment of the phenyl ring to the isoxazolering is presumed to enhance further the stability ofthe oxacillin congener dicloxacillin sodium, [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodiummonohydrate (Dynapen, Pathocil, Veracillin) and toproduce high plasma concentrations of it. Its medicinalproperties and use are similar to those of cloxacillinsodium. Progressive halogen substitution, however, alsoincreases the fraction bound to protein in the plasma, potentiallyreducing the concentration of free antibiotic inplasma and tissues. Its medicinal properties and use are thesame as those of cloxacillin sodium.