Doxorubicin hydrochloride manufacturers and suppliers in india

Doxorubicin hydrochloride

Properties

Melting point:: 216 °C (dec.)(lit.)

alpha: D20 +248±2° (c = 0.1 in methanol)

storage temp.: 2-8°C

solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.

pka: pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain)

form: solid

color: orange to dark red

Water Solubility: Soluble in water.

λmax: 497nm(H2O)(lit.)

Merck: 14,3439

BRN: 4229251

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

InChIKey: MWWSFMDVAYGXBV-RUELKSSGSA-N

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H302-H340-H350-H360FD

Precautionary statements: P201-P202-P264-P270-P301+P312-P308+P313

Hazard Codes: T,T+,Xi

Risk Statements: 45-22-40-26/27/28-36/38

Safety Statements: 53-45-36/37/39-22-7/9

WGK Germany: 3

RTECS: QI9295900

F: 10-21

HS Code: 29419090

Toxicity: LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)

Use

Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.