ETIZOLAM

CAS:: 40054-69-1

MF:: C17H15ClN4S

MW:: 342.85

Properties

Melting point:: 147-148℃

Boiling point:: 264.5°C (rough estimate)

Density: 1.43

refractive index: 1.6100 (estimate)

Flash point:: 9°C

storage temp.: -20°C

solubility: DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

form: A neat solid

pka: 2.37±0.40(Predicted)

Safety Information

Symbol(GHS): GHS02, GHS06, GHS08

Signal word: Danger

Hazard statements: H225-H301+H311+H331-H370

Precautionary statements: P210-P260-P280-P301+P310-P311

Hazard Codes: F,T

Risk Statements: 11-23/24/25-39/23/24/25

Safety Statements: 7-16-36/37-45

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 1

Toxicity: LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari)

Use

https://www.drugbank.ca/drugs/DB09166 https://en.wikipedia.org/wiki/Etizolam Casacchia, Massimo, F. Bolino, and U. Ecari. Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo.Current Medical Research Opinion 12.4(2008):215-223. Savoldi, F, G. Somenzini, and U. Ecari. Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study.Current Medical Research Opinion 12.3(1990):185. Hirashima, Y, et al. Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography. Neurologia medico-chirurgica 42.2(2002):53-55.

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