Famciclovir manufacturers and suppliers in india

Famciclovir

Properties

Melting point:: 102-104°C

Boiling point:: 550.2±60.0 °C(Predicted)

Density: 1.40±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: ≥10mg/mL

form: solid

pka: 4.00±0.10(Predicted)

color: White to Off-White

λmax: 310nm(EtOH)(lit.)

InChIKey: GGXKWVWZWMLJEH-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P280-P305+P351+P338

Hazard Codes: T

Risk Statements: 20/21/22-45-61

Safety Statements: 36/37/39-45-53-24/25

WGK Germany: 3

RTECS: TY3164000

HS Code: 29335990

Use

Famciclovir, an effective oral prodrug of the antiviral penciclovir, was launched in the UK and shortly after in the U.S.A. for the treatment of shingles (herpes zoster). As the diacetyl ester of the 6-deoxy- penciclovir, famciclovir has significantly improved oral absorption. It is converted to penciclovir in vivo with a bioavailability of 41 % in rats. Penciclovir is phosphorylated, and hence activated onty in herpesvirus infected cells. This stable metabolite, penciclovir-triphosphate, is a strong inhibitor of herpesvirus DNA polymerases and of viral DNA synthesis with long lasting effects. The high selectivity of famciclovir/penciclovir to herpes family of viruses and their rather low toxicity may make this agent superior to other existing drugs.