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FENTANYL
FENTANYL
- CAS:
- 437-38-7
- MF:
- C22H28N2O
- MW:
- 336.47
Properties
- Melting point:
- 83-84°C
- Boiling point:
- 466℃
- Density
- 1.087
- refractive index
- 1.6500 (estimate)
- Flash point:
- 186℃
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol
- pka
- 8.4(at 25℃)
- form
- A crystalline solid
- color
- Crystals
- Water Solubility
- 0.2g/L(25 ºC)
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H300+H310+H330-H336
- Precautionary statements
- P260-P262-P264-P280-P302+P352+P310-P304+P340+P310
- Hazard Codes
- F,T
- Risk Statements
- 11-23/25-36/38-39/23/24/25-23/24/25
- Safety Statements
- 16-24-45-36/37-7
- RIDADR
- 1544
- WGK Germany
- 2
- RTECS
- UE5550000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933330000
- Toxicity
- LD50 orl-rat: 18 mg/kg JPPMAB 25,929,73
Use
When the 4-phenyl substituent of meperidine was replaced with a 4-aniline with a nitrogen connection, the potency increased. This led to the development of the 4-anilidopiperidine series of compounds. Fentanyl (Sublimaze) was the first compound marketed and was found to be almost 500 times more potent than meperidine. The high lipophilicity of fentanyl gave it a quick onset, and the quick metabolism led to a short duration of action. The combination of potency, quick onset, and quick recovery led to the use of fentanyl as an adjunct anesthetic.
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