Fisetin manufacturers and suppliers in india

Fisetin

Properties

Melting point:: >330 °C(lit.)

Boiling point:: 348.61°C (rough estimate)

Density: 1.2981 (rough estimate)

refractive index: 1.4413 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: DMSO (Slightly), Methanol (Slightly)

form: Solid

Colour Index: 75620

pka: 6.83±0.40(Predicted)

color: Pale Yellow to Very Dark Yellow

Merck: 14,4088

BRN: 292829

Stability:: Hygroscopic

InChI: InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

InChIKey: XHEFDIBZLJXQHF-UHFFFAOYSA-N

SMILES: C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC=C2C(=O)C=1O

LogP: 1.970 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements: 36/37/38

Safety Statements: 22-24/25

WGK Germany: 3

RTECS: LK9250000

F: 10

TSCA: Yes

HS Code: 29329990

Use

Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).