Galangin manufacturers and suppliers in india

Galangin

Properties

Melting point:: 214-215 °C(lit.)

Boiling point:: 333.35°C (rough estimate)

Density: 1.2319 (rough estimate)

refractive index: 1.6000 (estimate)

storage temp.: room temp

solubility: Acetone (Slightly), Ethyl Acetate (Slightly)

form: Solid

pka: 6.32±0.40(Predicted)

color: Light Yellow to Yellow

Merck: 14,4339

BRN: 272179

InChIKey: VCCRNZQBSJXYJD-UHFFFAOYSA-N

LogP: 3.322 (est)

CAS DataBase Reference: 548-83-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-37/39

WGK Germany: 3

RTECS: LK9275500

F: 10

HS Code: 29329990

Use

Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).