Isoxazole manufacturers and suppliers in india

Isoxazole

Properties

Melting point:: -67.1°C

Boiling point:: 93-95 °C(lit.)

Density: 1.078 g/mL at 25 °C(lit.)

vapor density: 2.4 (vs air)

refractive index: n20/D 1.427(lit.)

Flash point:: 48 °F

storage temp.: 2-8°C

solubility: 167g/l

pka: -2.0(at 25℃)

form: clear liquid

color: Colorless to Light yellow

BRN: 103773

InChIKey: CTAPFRYPJLPFDF-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS02

Signal word: Danger

Hazard statements: H225

Precautionary statements: P210

Hazard Codes: F,Xi

Risk Statements: 11

Safety Statements: 16-23/33-33-29-7/9

RIDADR: UN 1993 3/PG 2

WGK Germany: 3

F: 10

Hazard Note: Highly Flammable

TSCA: Yes

HazardClass: 3

PackingGroup: II

HS Code: 29349990

Use

As an important class of heterocycles, isoxazole is a five membered heterocyclic compound with various pharmacological actions, which is found in some natural products, such as ibotenic acid. It is used in the formation of the basis for a number of drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV. The isoxazole ring is an essential pharmacophore in modern drug discovery. Some beta-lactamase-resistant antibiotics contain an isoxazole group, including cloxacillin, dicloxacillin, flucloxacillin, and the isoxazole group is also found in some steroid drug such as danazol.