Kanamycin sulfate manufacturers and suppliers in india

Kanamycin sulfate

Properties

Melting point:: 250°C

alpha: +112～+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)

Density: 1.3619 (rough estimate)

refractive index: 117.5 ° (C=1, H2O)

storage temp.: 2-8°C

solubility: H₂O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.

form: powder

color: white to off-white

PH Range: 6.5 - 8.5 (1% solution)

Water Solubility: Soluble in water at 10mg/ml

Merck: 14,5281

InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H360D

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: T

Risk Statements: 61

Safety Statements: 22-24/25-45-53

WGK Germany: 3

RTECS: NZ3225030

HS Code: 29419020

Toxicity: LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)

Use

It has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1 Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2