Loperamide
Loperamide
- CAS:
- 53179-11-6
- MF:
- C29H33ClN2O2
- MW:
- 477.04
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Properties
- Boiling point:
- 647.2±55.0 °C(Predicted)
- Density
- 1.187±0.06 g/cm3(Predicted)
- pka
- pKa 8.66(H2O) (Uncertain)
- BCS Class
- 4
- LogP
- 2.641 at 25℃ and pH6.95
- CAS DataBase Reference
- 53179-11-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Loperamide(53179-11-6)
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P264-P270-P301+P310-P321-P330-P405-P501
- Hazardous Substances Data
- 53179-11-6(Hazardous Substances Data)
Use
Loperamide (Imodium) is a 4-phenylypiperidine with amethadone-like structure attached to the piperidine nitrogen. It acts as an antidiarrheal by directly binding tothe opiate receptors in the gut wall. Loperamide inhibitsacetylcholine and prostaglandin release, decreasing peristalsisand fluid secretion thus increasing the GI transit time andreducing the volume of fecal matter.Loperamide is sufficiently lipophilic to cross the blood-brain barrier, yet itdisplays no CNS-opioid effects. The reason for this is that itis actively pumped out of the brain via the P-glycoproteinpump (MDR1). Knockout mice with the P-glycoproteinpump genetically removed were given radiolabeled loperamideand sacrificed 4 hours later. The [3H]loperamideconcentrations were measured and compared with wild-typemice. A 13.5-fold increase in loperamide concentration wasfound in the brain of the knockouts. In addition, the micelacking the P-glycoprotein pump displayed pronouncedsigns of central opiate agonism. Loperamide is availableas 2-mg capsules for treatment of acute and chronic diarrhea.Recommended dosage is 4 mg initially, with 2 mgafter each loose stool for a maximum of 16 mg/d.
5 India supplier list of "Loperamide"
- Product Name:Loperamide
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Loperamide 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl- 2,2-diphenylbutanamide
- Products Intro:Purity: 96% | Package: 25 mg, 50 mg , 100mg or 500 mg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Loperamide
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Loperamide
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Loperamide
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Loperamide
- Products Intro:Brand:pharmaffiliates | Product Number:PA1280000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Loperamide
- Products Intro:Brand:clearsynth | Product Number:CS-O-01787
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
$1.00/ 1KG
- Product Name:Loperamide
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:loperamide
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Loperamide USP/EP/BP
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA