Maxacalcitol manufacturers and suppliers in india

Maxacalcitol

CAS:: 103909-75-7

MF:: C26H42O4

MW:: 418.61

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Properties

Melting point:: 122°

alpha: D20 +49.4° (c = l.00 in ethanol)

Boiling point:: 581.4±50.0 °C(Predicted)

Density: 1.09±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Soluble in DMSO

form: crystalline solid

pka: 14.43±0.40(Predicted)

color: White to off-white

InChIKey: DTXXSJZBSTYZKE-ZDQKKZTESA-N

SMILES: [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H361

Precautionary statements: P281-P301+P310

Use

Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.