Mesna manufacturers and suppliers in india

Mesna

Properties

Melting point:: >240°C dec.

storage temp.: 2-8°C

solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane

form: Solid

color: White to Off-White

Water Solubility: Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).

Merck: 14,5909

BRN: 3657828

Stability:: Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 2

RTECS: KI7968000

HS Code: 2930 90 98

Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)

Use

Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.