Methyldopa
Methyldopa
- CAS:
- 555-30-6
- MF:
- C10H13NO4
- MW:
- 211.22
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Properties
- Melting point:
- ≥300 °C
- Boiling point:
- 350.89°C (rough estimate)
- Density
- 1.2545 (rough estimate)
- refractive index
- -14 ° (C=1, H2O)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble to 75 mM in DMSO
- pka
- 2.28±0.26(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- 10g/L(temperature not stated)
- Merck
- 14,6055
- BCS Class
- 3
- CAS DataBase Reference
- 555-30-6(CAS DataBase Reference)
- EPA Substance Registry System
- Methyldopa (555-30-6)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
- WGK Germany
- 3
- RTECS
- YP2860000
- F
- 10-23
- HS Code
- 29181990
- Hazardous Substances Data
- 555-30-6(Hazardous Substances Data)
- Toxicity
- LD50 oral in rabbit: 713mg/kg
Use
Methyldopa differs structurally from L-DOPA only in the presence of a -methyl group. Originally synthesized as an AADC inhibitor,methyldopa ultimately decreases the concentration of DA,NE, E, and serotonin in the CNS and periphery. However,its mechanism of action is not caused by its inhibition ofAADC but, rather, by its metabolism in the CNS to its activemetabolite ( β-methylnorepinephrine). Methyldopa istransported actively into CNS via an aromatic amino acidtransporter, where it is decarboxylated by AADC in thebrain to (1R,2S)- α-methyldopamine. This intermediate, inturn, is stereospecifically β-hydroxylated by DBH to givethe (1R,2S)-α-methylnorepinephrine. This active metaboliteis a selective α2-agonist because it has correct(1R,2S) configuration . It is currently postulated that α-methylnorepinephrine acts on α2-receptors in theCNS in the same manner as clonidine, to decrease sympatheticoutflow and lower blood pressure.
45 India supplier list of "Methyldopa"
- Product Name:Methyldopa
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Methyldopa
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Methyldopa
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Carbidopa EP Impurity A
- Products Intro:Purity: 98% | Package: 25mg, 50mg,100mg,200mg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Methyldopa
- Products Intro:Purity: 99% | Package: Kg to Mtons
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Methyldopa 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.195003
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Methyldopa
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Methyldopa
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Methyldopa
- Company Type: Reagent
- Country/Region: Delhi,INDIA
- Product Name:Methyldopa
- Company Type: Reagent
- Country/Region: Mumbai,INDIA