Olodaterol
Olodaterol
- CAS:
- 868049-49-4
- MF:
- C21H26N2O5
- MW:
- 386.44
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Properties
- Boiling point:
- 649.0±55.0 °C(Predicted)
- Density
- 1.250
- solubility
- DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- pka
- 9.42±0.20(Predicted)
- color
- Light yellow to khaki
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- H302-H319-H372
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501
Use
In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat? Soft Mist? inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC50=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.
1 India supplier list of "Olodaterol"
- Product Name:Olodaterol
- Products Intro:Brand:clearsynth | Product Number:CS-T-37875
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Olodaterol
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Olodaterol
- Products Intro:Brand:pharmaffiliates | Product Number:PA1530000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:olodaterol
- Products Intro:Purity: 0.99|Package: 1KG;50.00;USD
- Company Type: Manufacturer
- Country/Region: CHINA
- Main Products: lead acetate,Lead oxide,PMK ethyl glycidate,BMK Glycidic Acid,Diethyl(phenylacetyl)malonate
$50.00/ 1KG
- Product Name:6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
- Products Intro:Purity: 99% | Package: 100g ;1KG ;5KG 25KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: OLED/LCD chemicals,Reactive Mesogens,Silane,Silicon
- Product Name:Olodaterol
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
- Products Intro:Purity: 99% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$1.00/ 1KG
- Product Name:Olodaterol
- Products Intro:Package: 5mg | CustNote: BOC Sciences also provides custom synthesis services for Olodaterol.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:Olodaterol 6-Hydroxy-8-[(1r)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2h-1,4-benzoxazin-3(4h)-one
- Products Intro:Purity: 99% | Package: 1kg; 25kg; or larger package as required
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Specialty chemicals,OLED materials,Custom synthesis service