Quinidine sulfate dihydrate manufacturers and suppliers in india

Quinidine sulfate dihydrate

Properties

Melting point:: 212-214 °C (dec.)(lit.)

alpha: [α]D20 +260～+270° (c=5, dil. HCl.10min)

refractive index: 275 ° (C=2, 0.1mol/L HCl)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

solubility: Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone.

color: White to Off-White

Water Solubility: Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml).

Sensitive: Light Sensitive

Merck: 14,8060

InChIKey: AKYHKWQPZHDOBW-ZAXYGKDDNA-N

SMILES: [C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r|

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: Xn

Risk Statements: 22-20/21/22

Safety Statements: 13-36

RIDADR: UN 2811 6.1/PG III

WGK Germany: 3

RTECS: VA5605000

TSCA: Yes

HazardClass: 6.1

PackingGroup: III

HS Code: 2939200050

Use

Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate is bitter and light sensitive.Aqueous solutions are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform. Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.