Quinidine sulfate dihydrate
- CAS No.
- 6591-63-5
- Chemical Name:
- Quinidine sulfate dihydrate
- Synonyms
- Quinidin;Unii-J13S2394he;Pitayine Sodium;Chinidin Sodium;β-quinine Sodium;β-quinine Sodium;QUINIDINE SULFATE;(S) Quinine Sulfate;Quinidine sulfate CRS;QUINIDINE SULFATE 99+%
- CBNumber:
- CB2471189
- Molecular Formula:
- C20H26N2O6S
- Molecular Weight:
- 422.5
- MOL File:
- 6591-63-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/7 13:22:10
| Melting point | 212-214 °C (dec.)(lit.) |
|---|---|
| alpha | [α]D20 +260～+270° (c=5, dil. HCl.10min) |
| refractive index | 275 ° (C=2, 0.1mol/L HCl) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone. |
| color | White to Off-White |
| Water Solubility | Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml). |
| Sensitive | Light Sensitive |
| Merck | 14,8060 |
| InChIKey | AKYHKWQPZHDOBW-ZAXYGKDDNA-N |
| SMILES | [C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r| |
| CAS DataBase Reference | 6591-63-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-20/21/22 |
| Safety Statements | 13-36 |
| RIDADR | UN 2811 6.1/PG III |
| WGK Germany | 3 |
| RTECS | VA5605000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 2939200050 |
Quinidine sulfate dihydrate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | Q0875 | Quinidine sulfate salt dihydrate | 6591-63-5 | 10G | ₹9720.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Q0875 | Quinidine sulfate salt dihydrate | 6591-63-5 | 25G | ₹21379.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Q0875 | Quinidine sulfate salt dihydrate | 6591-63-5 | 50G | ₹40604.58 | 2022-06-14 | Buy |
| ALFA India | ALF-J60426-14 | Quinidine sulfate dihydrate, 98+% | 6591-63-5 | 25g | ₹15809 | 2022-05-26 | Buy |
| ALFA India | ALF-J60426-06 | Quinidine sulfate dihydrate, 98+% | 6591-63-5 | 5g | ₹3029 | 2022-05-26 | Buy |
Quinidine sulfate dihydrate Chemical Properties,Uses,Production
Description
Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. Quinidine sulfate dihydrate is a white, odorless crystalline substance that has a bitter flavor. It has limited solubility in water and alcohol but dissolves easily in chloroform and ether. This compound is effective against bacteria resistant to erythromycin, including staphylococci and streptococci, and works by inhibiting cellular ATPases.
Chemical Properties
Quinidine sulfate dihydrate is white to light yellow crystal powde
Uses
Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
Application
Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.
General Description
Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.
Hazard
Quinidine sulfate dihydrate is acutely toxic and photosensitising. The photosensitisation reaction to quinidine sulphate was reproducible in the photopic test and after oral administration plus ultraviolet A (UVA) irradiation. Eczematous dermatitis was induced after intradermal injection of quinidine sulfate dihydrate irradiated by UVA in vitro only in the presence of the patient's serum. Three workers exposed to quinidine sulphate developed allergic reactions within a short period of time (2-3 months).
Clinical Use
Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.
Quinidine sulfate dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Prism Industries Ltd | +91-9825050731 +91-9227406992 | Gujarat, India | 28 | 58 | Inquiry |
| Refsyn Biosciences Pvt., Ltd. | 91-413-2200273 | Tamil Nadu, India | 226 | 58 | Inquiry |
| Inga Pharmaceuticals (INGA) | 91-22-28202932 | Maharashtra, India | 9 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Prism Industries Ltd | 58 |
| Refsyn Biosciences Pvt., Ltd. | 58 |
| Inga Pharmaceuticals (INGA) | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Pharma Affiliates | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | 50 |
| Alfa Aesar | 58 |
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