STAUROSPORINE manufacturers and suppliers in india

STAUROSPORINE

Properties

Melting point:: 270°C

alpha: D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)

Boiling point:: 677.5±55.0 °C(Predicted)

Density: 1.56±0.1 g/cm3(Predicted)

RTECS: KD5084000

storage temp.: 2-8°C

solubility: DMSO: soluble

form: White to pale yellow solid

pka: 14.25±0.70(Predicted)

color: Off white to pale yellow

Water Solubility: Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.

BRN: 1060573

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.

InChIKey: HKSZLNNOFSGOKW-WIFUGMKFSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361d-H413

Precautionary statements: P201-P202-P273-P280-P308+P313-P405

Hazard Codes: Xn,T,Xi

Risk Statements: 40-45-36/37/38-46

Safety Statements: 36/37-53-36-26-45

RIDADR: UN 2811 6.1 / PGII

WGK Germany: 2

F: 8-10

HazardClass: 3

HS Code: 29419090

Use

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.