UNC 1999
UNC 1999
- CAS:
- 1431612-23-5
- MF:
- C33H43N7O2
- MW:
- 569.74
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 804.7±65.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 11.84±0.10(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChIKey
- DPJNKUOXBZSZAI-UHFFFAOYSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
- Hazard Codes
- Xn
- Risk Statements
- 22
- WGK Germany
- 3
Use
UNC1999 is highly potent for both EZH2 Y641N and EZH2 Y641F mutants in vitro. UNC1999 causes concentration-dependent reductions of H3K27me3 in MCF10A cells with IC50 of 124 nM , while shows low cellular toxicity. UNC1999 displays potent, concentration-dependent inhibition of cell proliferation with EC50 of 633 nM in a DLBCL cell line harboring the EZH2Y641N mutant. In addition, biotinylated UNC1999 enriches EZH2 from HEK293T cell lysates, and thus may be used in chemoproteomics studies.
1 India supplier list of "UNC 1999"
- Product Name:Unc1999 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.192593
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:UNC1999
- Products Intro:Brand:clearsynth | Product Number:CS-T-46122
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:UNC1999
- Products Intro:Brand:ajchemicals | Product Number:JDH-38372 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:UNC1999
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:UNC-1999
- Products Intro:Purity: 0.98 | Package: 25mg | CustNote: BOC Sciences also provides custom synthesis services for UNC-1999.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:N-[(6-methyl-2-oxo-4-propyl-1h-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
- Products Intro:Purity: 98.0%
- Company Type: Trader
- Country/Region: CHINA
- Product Name:UNC1999
- Products Intro:Purity: 0.98 | Package: mg,gram,kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: API,Dye Intermediate,Customized products,Peptide,Curing agent
- Product Name:UNC 1999
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA