UNC 0631
UNC 0631
- CAS:
- 1320288-19-4
- MF:
- C37H61N7O2
- MW:
- 635.93
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Properties
- Boiling point:
- 763.4±70.0 °C(Predicted)
- Density
- 1.114±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
- form
- solid
- pka
- 9.34±0.70(Predicted)
- color
- Light yellow to yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Use
UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.[Cayman Chemical]
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