veratramine manufacturers and suppliers in india

veratramine

CAS:: 60-70-8

MF:: C27H39NO2

MW:: 409.6

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Properties

Melting point:: 122-1240C

alpha: D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol)

Boiling point:: 529.83°C (rough estimate)

Density: 1.0393 (rough estimate)

refractive index: 1.6400 (estimate)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)

pka: 14.82±0.60(Predicted)

form: solid

color: Tan

λmax: 268nm(lit.)

Merck: 14,9952

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P501-P270-P264-P301+P310+P330-P405

RIDADR: UN 2811 6.1/PG III

RTECS: YX5094000

HS Code: 2933.39.4100

HazardClass: 6.1

PackingGroup: III

Use

The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer. Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM. Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.