| Company Name: |
Anyang Hongmeng New Materials Co., Ltd
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| Tel: |
19588588067 19588588067 |
| Email: |
19588588067@163.com |
| Products Intro: |
Cas:329-98-6
ProductName:Phenylmethanesulfonyl fluoride
Purity: 98%；99% | Package: 100g；500g；1kg；5kg；25kg
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| Company Name: |
Henan Vcommend Consultrading Co., Ltd.
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| Tel: |
13393721940 |
| Email: |
sales@vcommend.com |
| Products Intro: |
Cas:329-98-6
ProductName:Phenylmethanesulfonyl fluoride
Purity: 98.0% | Package: 25kg/drum
|
- Magnesium fluoride
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- $100.00 / 25kg
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2023-01-31
- CAS:7783-40-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 50000KG/month
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| | Phenylmethanesulfonyl Fluoride Basic information |
| Product Name: | Phenylmethanesulfonyl Fluoride | | Synonyms: | α-toluenesulphonyl fluoride;Phenylmethanesulfonyl fluoride,α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride;Phenylmethanesulfony;BENZYLSULFONYL FLUORIDE;A-TOLUENESULFONYL FLUORIDE;A-TOLUENESULPHONYL FLUORIDE;BENZENEMETHANESULFONYL FLUORIDE;P-TOLUENESULPHONYL FLUORIDE | | CAS: | 329-98-6 | | MF: | C7H7FO2S | | MW: | 174.19 | | EINECS: | 206-350-2 | | Product Categories: | Inhibitor;ProteaseInhibitors;329-98-6 | | Mol File: | 329-98-6.mol |  |
| | Phenylmethanesulfonyl Fluoride Chemical Properties |
| Melting point | 92-95 °C | | Boiling point | 112 °C16 mm Hg(lit.) | | density | 0.797 g/mL at 20 °C | | Fp | 222 °F | | storage temp. | 2-8°C | | solubility | dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C. | | form | Needles (May Agglomerate) | | color | White | | Water Solubility | hydrolysis | | Sensitive | Moisture Sensitive | | Merck | 14,7542 | | BRN | 2088311 | | Stability: | Moisture Sensitive | | InChIKey | YBYRMVIVWMBXKQ-UHFFFAOYSA-N | | CAS DataBase Reference | 329-98-6(CAS DataBase Reference) | | EPA Substance Registry System | Benzenemethanesulfonyl fluoride (329-98-6) |
| Hazard Codes | F,T,C | | Risk Statements | 11-34-25-23/24/25 | | Safety Statements | 7-16-45-36/37/39-28A-26-27 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | RTECS | XT8050000 | | F | 3-10-21 | | Hazard Note | Highly Toxic/Corrosive | | TSCA | T | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29241990 | | Toxicity | LD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky) |
| | Phenylmethanesulfonyl Fluoride Usage And Synthesis |
| Chemical Properties | White to cream solid | | Uses | PMSF is an irreversible serine/cysteine protease inhibitor | | Uses | Phenylmethylsulfonyl fluoride is used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase. | | Uses | Standard protease inhibitor in biological research; in protein purification to prevent proteolytic degradation. | | Definition | ChEBI: Phenylmethanesulfonyl fluoride is an acyl fluoride with phenylmethanesulfonyl as the acyl group. It has a role as a serine proteinase inhibitor. It derives from a phenylmethanesulfonic acid. | | General Description | In biochemistry, Phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor commonly used in preparation of cell lysates. It is rapidly degraded in water and stock solutions are usually made up in anhydrous ethanol, isopropanol, corn oil, or DMSO (Dimethyl sulfoxide).
| | Hazard | Extremely corrosive and destructive to tissues. May cause irreversible eye damage. PMSF hydrolyzes upon exposure to water/moisture, liberating a toxic and corrosive gas (hydrogen flouride) that in contact with metal surfaces can generate flammable and/or explosive hydrogen gas. | | Biological Activity | pmsf (phenylmethanesulfonyl fluoride) is an irreversible inhibitor of serine proteinases, which is associated with the development of the delayed organophosphorus neuropathy. it has a role in a lot of cellular repair and regeneration processes in many kinds of tissues. pmsf is a long acting neuropathy target esterase (nte) inhibitor. nte is a protection was related to inhibition of the putative target of organophosphate-induced delayed polyneuropathy (opidp). pmsf can increase nte inhibition to more than 90%. pmsf also acts as an active site directed reagent for γ-glutamyl transpeptidase.thomas baker, herbert e. lowndes, martin k. johnson, irene c. sandborg. the effects of phenylmethanesulfonyl fluoride on delayed organophosphorus neuropathy. archives of toxicology. 1980; 46(3-4): 305 – 311.marcello lotti, stefano caroldi, eugenio capodicasa, angelo moretto. promotion of organophosphate-induced delayed polyneuropathy by phenylmethanesulfonyl fluoride. toxicology and applied pharmacology. 1991; 108(2): 234 – 241.masayasu inoue, seikoh horiuchi, yoshimasa morino. inactivation of γ-glutamyl transpeptidase by phenylmethanesulfonyl fluoride, a specific inactivator of serine enzymes. biochemical and biophysical research communications. 1978; 82(4): 1183 – 1188. | | Biochem/physiol Actions | Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice. | | storage | Desiccate at RT | | storage | Phenylmethylsulfonyl fluoride (PMSF) is incompatible with water, acids, bases, and strong oxidizing agents. Do not store PMSF in glass or mild steel/galvanized containers. Store in a cool, dry, and well-ventilated area away from incompatible chemicals. | | Purification Methods | Purify PMSF by recrystallisation from *C6H6, pet ether or CHCl3/pet ether. [Davies & Dick J Chem Soc 483 1932, cf Tullock & Coffman J Org Chem 23 2016 1960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney & Gould J Am Chem Soc 85 997 1963]. [Beilstein 11 III 331.] |
| | Phenylmethanesulfonyl Fluoride Preparation Products And Raw materials |
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