2,3-吡啶二羧酸
中文名称 | 2,3-吡啶二羧酸 |
---|---|
中文同义词 | 2,3-吡啶二羧酸(吡啶-2,3-二羧酸、喹啉酸、吡啶-2,3-二酸、吡啶羧酸、吡啉酸、2,3-二羧酸基吡啶);喹啉酸 25G;吡啶-2,3-二酸;吡啶羧酸;吡啉酸;吡啶-2,3-二羧酸;喹啉酸;吡啶2,3-二羧酸 (喹啉酸) |
英文名称 | Quinolinic acid |
英文同义词 | QuinolinicAcid>99%;Pyridin-2,3-dicarbonsaeure;2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID);2,3-pyridine dicarbo;AKOS BBS-00003814;AKOS AUF2085;Quinolinic Acid 99%;2,3-Pyridinedicarboxylic acid, 99% 100GR |
CAS号 | 89-00-9 |
分子式 | C7H5NO4 |
分子量 | 167.12 |
EINECS号 | 201-874-8 |
相关类别 | 通用试剂;原料;有机化工;医药原料;中间体;医药中间体;除草剂中间体;咪唑啉酮类除草剂;农药中间体;吡啶;杂环砌块;吡啶类;化工中间体;有机化工原料;有机原料;Medical Intermediates;Pyridine series;Pyridine;pyridine derivative;Carboxylic Acids;Pyridines;Heterocyclic Compounds;Heterocycles;Inhibitors;Carboxylic Acids;Aromatics;其他原料;化工原料-塑料类;化工中间体工业原料;原料药;有机化工原料;化妆品原料;化工原料;杂质对照品;对照品;Intermediates & Fine Chemicals;Pharmaceuticals;Pesticides intermediate;Pyrimidines |
Mol文件 | 89-00-9.mol |
结构式 | ![]() |
2,3-吡啶二羧酸 性质
熔点 | 188-190 °C (dec.) (lit.) |
---|---|
沸点 | 295.67°C (rough estimate) |
密度 | 1.5216 (rough estimate) |
折射率 | 1.6280 (estimate) |
储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
溶解度 | 10g/l |
形态 | 结晶粉末 |
酸度系数(pKa) | 2.43(at 25℃) |
颜色 | 白色至浅黄米色 |
气味 (Odor) | 无味 |
水溶解性 | 0.55 g/100 mL |
Merck | 14,8073 |
BRN | 137110 |
InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
CAS 数据库 | 89-00-9(CAS DataBase Reference) |
EPA化学物质信息 | 2,3-Pyridinedicarboxylic acid (89-00-9) |
2,3-吡啶二甲酸为无色柱状结晶状,微溶于水,不溶于苯和醚。其可用做医药中间体,农药中间体,有机合成试剂。
用途
吡啶-2,3-二羧酸是除草剂咪唑烟酸的中间体。用途
抑制葡萄糖的合成用途
喹啉酸是一种具有吡啶骨架的二羧酸,是合成烟酸、菸酰胺、尼可刹米等的中间体,也是铜离子测定试剂。生产方法
其制备方法是以丙烯醛与草酰乙酸二乙酯、氯化铵为原料,在乙醇中催化剂存在下,反应加热回流,冷却得吡啶-2,3二羧酸酯再水解得产品。生产方法
用喹啉以硝酸氧化制得。安全信息
危险品标志 | Xi |
---|---|
危险类别码 | 36/37/38-33 |
安全说明 | 26-36/37-24/25-37 |
WGK Germany | 3 |
RTECS号 | US7967250 |
TSCA | T |
危险等级 | IRRITANT |
海关编码 | 29333999 |
毒害物质数据 | 89-00-9(Hazardous Substances Data) |
毒性 | Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur. |
提供商 | 语言 |
---|---|
英文
|
|
英文
|
|
英文
|
|
中文
|
|
英文
|