己曲安奈德
中文名称 | 己曲安奈德 |
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中文同义词 | 曲安西龙叔丁乙酸酯;己曲安奈德;化合物 T17162;己曲安奈德(16,17-异丙烯二酮-D6,98%);己曲安奈德 USP标准品;己曲安西龙 标准品;己曲安奈德 EP标准品 |
英文名称 | Triamcinolone hexacetonide |
英文同义词 | lic16,17-acetalwithacetone,21-(3,3-dimethylbutyrate);tatba;TRIAMCINOLONE HEXACETONIDE;Triamcinolone hexatonide;TRIAMCINOLONEHEXACETONIDE,USP;21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;9-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione 21-(3,3-dimethylbutyrate);C08185 |
CAS号 | 5611-51-8 |
分子式 | C30H41FO7 |
分子量 | 532.64 |
EINECS号 | 227-031-4 |
相关类别 | 医药原料药;化学试剂;Steroid and Hormone |
Mol文件 | 5611-51-8.mol |
结构式 |
己曲安奈德 性质
熔点 | 295-296° (dec); mp 271-272° (dec) |
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比旋光度 | D25 +90±2° (c = 1.13% in chloroform) |
沸点 | 619.5±55.0 °C(Predicted) |
密度 | 1.1277 (estimate) |
储存条件 | 2-8°C |
溶解度 | 几乎不溶于水,微溶于无水乙醇和甲醇。 |
形态 | 固体 |
酸度系数(pKa) | 13.09±0.70(Predicted) |
颜色 | 精细的白色针状晶体 |
EPA化学物质信息 | Triamcinolone hexacetonide (5611-51-8) |
Triamcinolone hexacetonide produces a marked, dose-dependent protective effect in the model of chemically induced articular cartilage damage. Guinea pig injected with Triamcinolone hexacetonide shows much less prominent fibrillation and osteophytes. Cell loss is less extensive. A single injection of Triamcinolone hexacetonide into the ipsilateral knee of rabbits which have been subjected to partial lateral meniscectomy and transection of the sesamoid and collateral fibular ligaments reduces chondrocyte cloning, loss of cells, osteophyte formation, and fibrillation. The half-life of commercially available Triamcinolone hexacetonide in the vitreous is double that of Triamcinolone hexacetonide, but the former is toxic to the retina in this rabbit model. Reformulated iso-osmolar Triamcinolone hexacetonide shows no evidence of deleterious effects to retina function or structure. Local application of Triamcinolone hexacetonide at a site of lingual nerve injury leads to changes that are potentially beneficial such as reduced mechanical sensitivity and enhanced regeneration.
安全信息
WGK Germany | 3 |
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海关编码 | 2937220000 |