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Product Name:PROTAC CDK2/9 Degrader-1 CAS:2408641-24-5 Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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Jilin Province Woda Biotechnology Co., Ltd.
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Product Name:4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutanoyl)piperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide CAS:2408641-24-5 Purity:99% HPLC Package:1克;5克;
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cjbscvictory
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13348960310 13348960310 |
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3003867561@qq.com |
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Product Name:PROTAC CDK2 CAS:2408641-24-5 Purity:98% Package:5mg;10mg;20mg;50mg;100mg;200mg
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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0431-80514535 19917294565 |
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caoy@chemextension.com |
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Product Name:4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutanoyl)piperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide CAS:2408641-24-5 Purity:95%+ Package:1g;5g;10g;25g;50g;100g;
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| PROTAC CDK2/9 Degrader-1 Basic information |
Product Name: | PROTAC CDK2/9 Degrader-1 | Synonyms: | PROTAC CDK2/9 Degrader-1;PROTAC CDK2;4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-(4-((2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)amino)-4-oxobutanoyl)piperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide;N-{4-[(4-{3-[(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethyl)carbamoyl]propanoyl}piperazin-1-yl)methyl]phenyl}-4-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1H-pyrazole-3-carboxamide | CAS: | 2408641-24-5 | MF: | C40H41N13O7 | MW: | 815.84 | EINECS: | | Product Categories: | | Mol File: | Mol File | |
| PROTAC CDK2/9 Degrader-1 Chemical Properties |
density | 1.534±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 130 mg/mL (159.34 mM; Need ultrasonic) | form | Solid | pka | 10.74±0.40(Predicted) | color | White to yellow |
| PROTAC CDK2/9 Degrader-1 Usage And Synthesis |
Biological Activity | PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with CRBN ligand[1].
PROTAC CDK2/9 Degrader-1 (0.25-3 μM; 48 hours) induces cell cycle blockage at the G2/M phase[1].PROTAC CDK2/9 Degrader-1 (500 nM; 2-24 hours) down-regulates the Mcl-1 protein level in PC-3 cells[1].PROTAC CDK2/9 Degrader-1 effectively degrades CDK2/9 in cell lines MCF-7, HCT-116 and 22Rv1, which all have high CDK2/9 expression[1].PROTAC CDK2/9 Degrader-1 inhibits both CDK2 and CDK9, with IC50 as 7.42 nM and 14.50 nM, respectively[1]. | References | [1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952. |
| PROTAC CDK2/9 Degrader-1 Preparation Products And Raw materials |
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