| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:PROTAC ER Degrader-3
CAS:2158322-29-1
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| | PROTAC ER Degrader-3 Basic information |
| Product Name: | PROTAC ER Degrader-3 | | Synonyms: | PROTAC ER Degrader-3;Carbamic acid, N-[(1S)-2-[[(3S,4S)-7-cyano-2,3,4,5-tetrahydro-5-[4-[[[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]amino]carbonyl]benzoyl]-1-[(2-methoxy-1-naphthalenyl)methyl]-4-methyl-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-...;Carbamic acid, N-[(1S)-2-[[(3S,4S)-7-cyano-2,3,4,5-tetrahydro-5-[4-[[[2-[2-[2-[[2-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]methylamino]-2-oxoethoxy]ethoxy]ethyl]amino]carbonyl]benzoyl]-1-[(2-methoxy-1-naphthalenyl)methyl]-4-methyl-2-oxo-1H-1,5-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-N-methyl-, 1,1-dimethylethyl ester | | CAS: | 2158322-29-1 | | MF: | C71H77N7O12 | | MW: | 1220.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2158322-29-1.mol |  |
| | PROTAC ER Degrader-3 Chemical Properties |
| Boiling point | 1264.4±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.38±0.15(Predicted) |
| | PROTAC ER Degrader-3 Usage And Synthesis |
| Description | PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound LP2. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
| | References | [1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1. |
| | PROTAC ER Degrader-3 Preparation Products And Raw materials |
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