- 6-Nitro-1H-indazole
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- $0.00 / 25kg
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2024-07-17
- CAS:7597-18-4
- Min. Order: 1kg
- Purity: ≥98% by HPLC
- Supply Ability: 100kg/month
- 6-Nitroindazole
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- $0.00/ kg
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2024-05-09
- CAS:7597-18-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1 ton
- 6-nitroindazole
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- $48.00 / 1KG
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2023-05-04
- CAS:7597-18-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20 tons
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| 6-Nitroindazole Basic information |
| 6-Nitroindazole Chemical Properties |
| 6-Nitroindazole Usage And Synthesis |
Description | 6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].
| Chemical Properties | yellow powder | Uses | Anticonvulsant. | Synthesis | 6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated acetonitrile.![6-Nitroindazole 6-Nitroindazole](/NewsImg/2023-11-08/6383503598119628995702537.png) | References | [1] HERRAIZTOMAS GuillénHugo AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170. |
| 6-Nitroindazole Preparation Products And Raw materials |
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