Метансульфонилхлорид химические свойства, назначение, производство
Химические свойства
Colorless to yellow liquid
Использование
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.
Общее описание
A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.
Профиль реактивности
Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Угроза здоровью
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Пожароопасность
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Возможный контакт
Chemical intermediate in various
industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical
stabilizer. Laboratory chemical.
Перевозки
UN3246 Methanesulfonyl chloride, Hazard Class
6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive
material, Inhalation Hazard Zone B.
Методы очистки
Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]
Несовместимости
Vapors may form explosive mixture with
air. Slowly reacts with water, releasing toxic and corrosive
hydrogen chloride gas. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, DMSO,
ethers, strong acids, strong bases.
Утилизация отходов
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed
Метансульфонилхлорид препаратная продукция и сырье
сырьё
препарат
Нимесулид
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt
Азтреонам
2-(Methanesulfonylamino)phenylboronic acid
Амсакрин
Ралоксифен
1,3-пропан сультон
5-аминосалициловая кислота
1-(Tetrahydro-2H-pyran-4-yl)hydrazine
Бусульфан
(4S)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-en-1-one
Олсалазин
Метансульфонамид
(-)-ДИОП
Cefcapene pivoxil
3-(METHANESULFONYLAMINO)BENZOIC ACID
Метил метансульфона
Гестоден
Перголид
Этил метансульфона
Halobetasol propionate
Ставудин
Этиловый methylsulfonylacetate
4-(Methylsulfonamido)aniline
Фексофенадин
TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE
(2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE
3-(BOC-амино)пирролидин
(4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE
2-амино-4 ,5-дифторбензойную кисло
4-(METHANESULFONYLAMINO)BENZOIC ACID
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate
Саперконазол
alkyl phenylsufonate
N-(3-Aminophenyl)methanesulfamide
optically active amino thioacetes
(3S,4S)-(-)-1-БЕНЗИЛ-3,4-БИС(ДИФЕНИЛФОСФИНО)ПИРРОЛИДИН
(2S, 4S)-1-Boc-4-дифенилфосфино-2-(diphenylphosphinomethyl) пирролидина
(S) - (-) -3 - (Boc-амино) пирролидин
Лимапрост