5-Бром-7-азаиндол
5-Бром-7-азаиндол атрибут
Температура плавления: |
176-180 °C |
Температура кипения: |
357.4±42.0 °C(Predicted) |
плотность: |
1.79±0.1 g/cm3(Predicted) |
температура хранения: |
Sealed in dry,Room Temperature |
пка: |
6.25±0.20(Predicted) |
форма: |
Кристаллический порошок |
цвет: |
От белого до желтого |
InChI: |
InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10) |
ИнЧИКей: |
LPTVWZSQAIDCEB-UHFFFAOYSA-N |
SMILES: |
C12NC=CC1=CC(Br)=CN=2 |
LogP: |
1.8 at 25℃ and pH7 |
Справочник по базе данных CAS: |
183208-35-7(CAS DataBase Reference) |
5-Бром-7-азаиндол химические свойства, назначение, производство
Химические свойства
White to light brown powder or crystal
Синтез
In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20
mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml),
40 ℃ stirring for 2 hours, the reaction is completed, to remove the
ethanol, add 50 ml of water residue is completely dissolved,
saturated NaHCO3 solution and to pH=8, and filtering the resulting solid,
after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g,
60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of
the reaction, rotary evaporated to remove chloroform, adding 50 ml
saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined
organic phase with water (50 ml) for washing and then the saturated salt
water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate
is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b]
pyridine the crude product, the crude product is chloroform: hexane=2:1
(volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield
77.6%, melting point:176.8-177.3 ℃.
Растворимость в органика
The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.
5-Бром-7-азаиндол препаратная продукция и сырье
сырьё
Цинк
7-азаиндол
трет-Бутанол
Диэтилэфирата трехфтористого бора
Бром
Кислота уксусная
Марганец(III) ацетат дигидрат
1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-
Acetamide, N-[5-bromo-3-[2-(trimethylsilyl)ethynyl]-2-pyridinyl]-
5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE
3,3,5-Tribromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
2-аминопиррол
5-бром-3-этинилпиридин-2-амин
Метил 5-бром-7-азаиндол-3-карбоксилат
5-БРОМ-3-((ТРИМЕТИЛСИЛИЛ)ЭТИНИЛ)ПИРИДИН-2-АМИН
5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE
4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o
препарат
5-Бром-7-азаиндол поставщик
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