Sertraline hydrochloride
|
79559-97-0
|
- CAS №
- 79559-97-0
- английское имя:
- Sertraline hydrochloride
- Синонимы:
- SETRALINE HCL;SERTRALINE MANDELATE;Sertraline hydrochlo;Sertraline hydrochloride impurity standard;N-(4(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)NAPHTHALIDENE) METHANAMINE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-Dichlorophenyl)-N-Methyl-1,2,3,4-tetrahydronaphthalen-1-aMine hydrochloride;CP-51974-1;(1s-cis)-lorid;CP-51974-1 HCl
- CBNumber:
- CB8157645
- Формула:
- C17H18Cl3N
- молекулярный вес:
- 342.69
- MOL File:
- 79559-97-0.mol
|
Sertraline hydrochloride атрибут
| Температура плавления: |
246-249°C |
| альфа: |
D23 +37.9° (c = 2 in methanol) |
| плотность: |
1.37 |
| Fp: |
9℃ |
| температура хранения: |
2-8°C |
| растворимость: |
ДМСО: ~ 26 мг/мл |
| форма: |
Твердый |
| пка: |
pKa (water): 9.48 ± 0.04; pKa (methanol:water, 40:60 v/v): 8.6; pKa (ethanol:water, 1:1 v/v): 8.5(at 25℃) |
| цвет: |
белый |
| оптическая активность: |
[α]/D +33 to +43°, c =2.0 in methanol |
| Мерк: |
14,8467 |
| Стабильность:: |
Хранить в морозильной камере |
| Справочник по базе данных CAS: |
79559-97-0(CAS DataBase Reference) |
| FDA UNII: |
UTI8907Y6X |
| Словарь наркотиков NCI: |
sertraline hydrochloride |
| UNSPSC Code: |
41116107 |
| NACRES: |
NA.77 |
Sertraline hydrochloride химические свойства, назначение, производство
Описание
Sertraline hydrochloride is a selective serotonin reuptake inhibitor, similar mechanistically
to fluoxetine, introduced initially for the maintenance and long-term treatment of
depression. It is reportedly non-sedating and compared to fluoxetine has a shorter duration
of action and lack of CNS activating effects such as nervousness and anxiety. Sertraline
hydrochloride is currently undergoing investigation for the treatment of obesity and
obsessive-compulsive disorders.
Химические свойства
White or almost white, crystalline powder.
Использование
The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.
Определение
ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride. A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive diso
der, panic disorder and post-traumatic stress disorder.
Общее описание
Sertraline, marketed as the brand drug Zoloft?, is an SSRI antidepressant used in the treatment of major depression as well as obsessive-compulsive, panic, and social anxiety disorders. This Certified Snap-N-Spike? Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis.
Биологическая активность
Potent, orally active selective serotonin re-uptake inhibitor (SSRI) used clinically to treat depression.
Sertraline hydrochloride препаратная продукция и сырье
сырьё
препарат
Sertraline hydrochloride поставщик
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