4-(Pyridin-3-yl)pyrimidin-2-amine
4-(Pyridin-3-yl)pyrimidin-2-amine атрибут
Температура плавления: |
189-191 °C |
Температура кипения: |
439.9±37.0 °C(Predicted) |
плотность: |
1.259±0.06 g/cm3(Predicted) |
температура хранения: |
under inert gas (nitrogen or Argon) at 2–8 °C |
растворимость: |
ДМСО (Мало растворим), метанол (Мало растворим) |
форма: |
Твердый |
пка: |
2.76±0.10(Predicted) |
цвет: |
От белого до бледно-желтого |
InChI: |
InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13) |
ИнЧИКей: |
LQHQKYWYKPLKCH-UHFFFAOYSA-N |
SMILES: |
C1(N)=NC=CC(C2=CC=CN=C2)=N1 |
4-(Pyridin-3-yl)pyrimidin-2-amine химические свойства, назначение, производство
Химические свойства
White to off-white or brown solid.
Использование
4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.
Синтез
3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).
4-(Pyridin-3-yl)pyrimidin-2-amine препаратная продукция и сырье
сырьё
препарат
4-(Pyridin-3-yl)pyrimidin-2-amine поставщик
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