Амитраз химические свойства, назначение, производство
Химические свойства
Amitraz forms colorless needle-like crystals.
Liquid formulations may contain flammable organic solvents.
Использование
Amitraz is an antiparasitic used to control red spider mites, leaf miners and scale insects. This compound is active by inhibiting the targets monoaminooxidase enzyme.
Определение
ChEBI: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
Общее описание
White monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.
Реакции воздуха и воды
Insoluble in water.
Профиль реактивности
Unstable in acid.
Сельскохозяйственное использование
Insecticde, Acaricide, Veterinary medicine: Registered for control of pear psylla on pears, whitefly and mites on pears and cotton; cattle, dogs, sheep, and
hog dip to control ticks, mange mites, lice and other pests.
Not permitted on apples. Used to control red spider mites,
leaf miners, scale insects, and aphids. Also used on cotton
to control bollworms, white fly, leaf worms, and tobacco
budworms. Not registered for use in EU countries
Торговое название
AAZDIENO®; ACARAC®; ACADREX®;
ARMY®; AZODIENO®; BAAM®; BOOTS BTS
27419®; BTS 27,419®; BUMETRAN®; COYOTE®;
DANICUT®; ECTODEX®; EDRIZAN®; EDRIZAR®;
GARIAL®; ISTAMBUL®; MITABAN®; MITAC®;
OVASYN®; OVIDREX®; PARSEC®; ROTRAZ®;
SENDER®; TAC-PLUS®; TACTIK®; TRIATIX®;
TRIATOX®; TUDY®; VAPCOZIN TAKTIC®; UPJOHN
U-36059®
Фармаколо?гия
The mechanism of action of amitraz has not been
completely elucidated, and, presently, a dual mode of
action appearsmost likely. Firstly, the enzymemonoamine
oxidase, which metabolizes neurotransmitter amines in
mites and ticks, is inhibited. Secondly, octopamine
receptors in the central nervous system of ectoparasites
are activated by amitraz, thereby modifying tonic muscle
contractions. The effect of amitraz is to induce increased
neuronal activity, abnormal behavior, detachment, and
death of mites and ticks.
Возможный контакт
Those engaged in the manufacture, formulation
and application of this insecticide and acaricide. A
rebuttable presumption against registration for amitraz was
issued on April 6, 1977 by United States Environmental
Protection Agency on the basis of oncogenicity.
Incompatibilities: Keep away from strong oxidizers and
strong acids. Acids may render this material unstable.
Метаболический путь
14C-Amitraz is applied on lemons grown under
glasshouse conditions at final harvest and the applied
radioactivity is quantitatively recovered, predominantly
in the peel (86%). The total residue at harvest
contains amitraz, N-methyl-N'-(2,4-xylyl)formamidine,
and formyl-2',4'-xylydine and conjugates of 4-amino-
m-toluic acid and the conjugated metabolites which
are convertible to 2,4-xylidine. Amitraz is readily
hydrolyzed at low pH values, forming acid-stable
formyl-2,4-xylydine which can be further hydrolyzed to
2,4-xylidine.
Метаболизм
Amitraz is poorly absorbed when applied topically to
animals. By contrast, orally administered amitraz is
rapidly and extensively absorbed. The metabolism and
excretion of amitraz are also rapid. It is hydrolyzed to
N-(2,4-dimethylphenyl)-N -methyl formamidine and 2,4-
dimethyl formamidine and the final product, 4-amino-3-
methylbenzoic acid, is converted to non-toxic conjugates.
The latter are excreted in the urine and, to a lesser extent,
in bile.
Перевозки
UN2763 Triazine pesticides, solid, toxic, Hazard
Class: 6.1; Labels: 6.1-Poisonous materials.
Несовместимости
Those engaged in the manufacture, formulation
and application of this insecticide and acaricide. A
rebuttable presumption against registration for amitraz was
issued on April 6, 1977 by United States Environmental
Protection Agency on the basis of oncogenicity.
Incompatibilities: Keep away from strong oxidizers and
strong acids. Acids may render this material unstable.
Утилизация отходов
In accordance with 40CFR
165 recommendations for the disposal of pesticides and
pesticide containers. Must be disposed properly by following
package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office.
Амитраз препаратная продукция и сырье
сырьё
препарат