Meropenem manufacturers and suppliers in india

Meropenem

Properties

Boiling point:: 627.4±55.0 °C(Predicted)

Density: 1.42±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: insoluble in EtOH; ≥19.15 mg/mL in DMSO; ≥9.88 mg/mL in H2O with ultrasonic

form: solid

pka: 4.27±0.60(Predicted)

color: White to off-white

InChI: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1

InChIKey: DMJNNHOOLUXYBV-PQTSNVLCSA-N

SMILES: N12[C@@]([H])([C@@H]([C@H](O)C)C1=O)[C@@H](C)C(S[C@H]1C[C@@H](C(N(C)C)=O)NC1)=C2C(O)=O

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H335-H315-H319

Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-37/39

HS Code: 29419000

Use

Meropenem is a new carbapenem antibiotic introduced to market for the i.v. treatment of a wide variety of hospital infections such as lower respiratory tract, urinary tract, intraabdominal, gynecological and polymicrobial infections. Meropenem has a broad spectrum of antibacterial activity against most clinically important Gram-positive and Gramnegative aerobic and anaerobic bacteria with especially high potency against multiresistant Enterobacteriaceae and Pseudornonas aeruginosa. Compared with imipenem, the only other available carbapenem antibiotic, meropenem has the advantage of being dehydropeptidase 1 (DHP-1) stable and therefore does not need to be administered in conjunction with the DHP-1 inhibitor cilastatin. Meropenem is also being evaluated for treatment of resistant pseudomonal infections in cystic fibrosis patients.